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Systematic Reviews: Steps in a Systematic Review

A Guide to Conducting Systematic Reviews

Systematic review process diagram

Identify the issue and determine the question. Write a plan for the review (protocol). Search for studies. Sift and select studies. Extract data from the studies. Assess the quality of the studies. Combine the data (synthesis or meta-analysis). Discuss and conclude overall findings), systematic review and dissemination.

This diagram illustrates in a visual way and in plain language what review authors actually do in the process of undertaking a systematic review.

Designed by Jessica Kaufman, Cochrane Consumers & Communication Review Group, Centre for Health Communication & Participation, La Trobe University, 2011. CC-BY-SA License.

Steps in the Systematic Review Process

  1. Check for existing reviews/protocols. Is the review still needed? Can you change the question to answer a different altered question? Was the review done well? When was it done? Has there been a development in the research since then? Is it broad enough? 
  2. Identify your research question.  Formulate a clear, well-defined research question of appropriate scope. Define your terminology. Find existing reviews on your topic to inform the development of your research question, identify gaps, and confirm that you are not duplicating the efforts of previous reviews. Consider using a framework to define you question scope.
  3. Define inclusion and exclusion criteria. This is also known as creating a review protocol. Clearly, state the criteria you will use to determine whether or not a study will be included in your search.  Consider study populations, study design, intervention types, comparison groups, measured outcomes.
  4. Search for studies. Run your searches in the databases that you've identified as relevant to your topic. Work with a librarian to help you design comprehensive search strategies across a variety of databases. Approach the gray literature methodically and purposefully. Collect ALL of the retrieved records from each search into a reference manager, such as Endnote, and de-duplicate the library prior to screening.
  5. Select studies for inclusion based on pre-defined criteria. Start with a title/abstract screening to remove studies that are clearly not related to your topic. Use your inclusion/exclusion criteria to screen the full-text of studies. It is highly recommended that two independent reviewers screen all studies, resolving areas of disagreement by consensus.
  6. Extract data from included studies. Use a spreadsheet, or systematic review software, to extract all relevant data from each included study. It is recommended that you pilot your data extraction tool, to determine if other fields should be included or existing fields clarified.
  7. Evaluate the risk of bias of included studies. Use a Risk of Bias tool (such as the Cochrane RoB Tool) to assess the potential biases of studies in regards to study design and other factors. You can adapt existing tools to best meet the needs of your review, depending on the types of studies included.
  8. Present results and assess the quality of evidence. Clearly present your findings, including detailed methodology (such as search strategies used, selection criteria, etc.) such that your review can be easily updated in the future with new research findings. Perform a meta-analysis if the studies allow. Provide recommendations for practice and policy-making if sufficient, high-quality evidence exists, or future directions for research to fill existing gaps in knowledge or to strengthen the body of evidence
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